chlorella side effects liver

chlorella side effects liver

Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding. Hot water extract of C. vulgaris triggered the death of human liver cancer cells by increasing p53, Bax, and caspase-3. Ever try supplements that don’t seem to work? They should guide further investigation but shouldn’t be interpreted as supportive of the anticancer effects until more research is done. Ohtake, T., Negishi, K., Okamoto, K., Oka, M., Maesato, K., Moriya, H., and Kobayashi, S. Manganese-induced Parkinsonism in a patient undergoing maintenance hemodialysis. Although it was beneficial for decreasing heart disease risk factors and fat cell size, there was no significant evidence that it could help with weight loss [13]. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Chlorella may also cause photosensitivity, increasing the risk of sun rash and sunburn. C. vulgaris extract improved allergic inflammation in mice by inhibiting IL-5 production (IgE-dependent) and reducing the recruitment of major inflammatory cells to the allergic airways (eosinophils and neutrophils). People respond differently to diets and supplements because everyone has unique DNA. C. vulgaris extract increased the lifespan of mice with tumors by stimulating the production of white blood cells (granulocytes and macrophages) [55]. No clinical evidence supports the use of Chlorella for any of the conditions listed in this section. C. vulgaris also suppressed histamine release in mice mast cells by inducing Th1 IFN-gamma and IL-12 production [54]. Side Effects of Chlorella ♦ Some people are known to suffer from stomach problems, diarrhea, water retention, flatulence, green discoloration of stool, and nausea. Konishi F, Tanaka K, Himeno K, et al. Int J Antimicrob Agents 2000;15:235-7.. View abstract. View abstract. However, there is no evidence to support this statement [82]. Please check with your GP before trying any remedies. Fibromyalgia. Chlorella interacts with warfarin, by decreasing its anticoagulant effect and increasing platelet aggregation [85, 86]. It protected rats against cadmium liver toxicity by decreasing cadmium accumulation and stimulating the expression of metallothioneins in the liver. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. Kurume Med J 2018;64(4):83-90. Green discoloration of stools 3. Chlorella’s impressive nutritional profile has led some to call it a “super food.” While … Chlorella supplements aren’t approved for cancer prevention or treatment. Dizziness 7. View abstract. Hot water extract of C. vulgaris increased the lifespan of skin cells (fibroblasts) from both young and old individuals [61, 62]. The detox reactions come from the release of more toxins than the chlorella can bind so more is better not worse. (2009) ^ a b c Mizoguchi T, et al. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]. To reduce the risk of side effects treatment duration should be as short as possible. Wu, L. C., Ho, J. To be safe, take a smaller "test" dose of chlorella and wait 24 to 48 hours to see if any allergy symptoms develop. This survey is being conducted by the WebMD marketing sciences department. Parachlorella beijerinckii accelerated the excretion of methylmercury and consequently decreased tissue levels of mercury in mice [42]. Headaches 6. View abstract. Chlorella is a source of Chlorophyll, Protein, Iron, Magnesium, and amino acids, but it … Anyone who is allergic to mold could find themselves allergic to chlorella as well. Kralovec, J. By helping the blood clot, chlorella might decrease the effectiveness of warfarin (Coumadin). Ng, T. P., Tan, W. C., and Lee, Y. K. Occupational asthma in a pharmacist induced by Chlorella, a unicellular algae preparation. Warfarin (Coumadin) interacts with CHLORELLA. Halperin SA, Smith B, Nolan C, et al. A study in pregnant mice revealed how C. pyrenoidosa suppressed methylmercury transfer to the fetus and reduced its accumulation in the mothers’ brains [44]. Pugh, N., Ross, S. A., ElSohly, H. N., ElSohly, M. A., and Pasco, D. S. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa. Proteins, selenium and sulphur-containing amino acids are also helpful in combating mercury. Am J Kidney Dis 2005;46(4):749-753. Allergy 1990;45(7):481-486. A., Metera, K. L., Kumar, J. R., Watson, L. V., Girouard, G. S., Guan, Y., Carr, R. I., Barrow, C. J., and Ewart, H. S. Immunostimulatory principles from Chlorella pyrenoidosa--part 1: isolation and biological assessment in vitro. Chlorella improved the elimination of radioactive strontium from mice through adsorption in the intestines [43]. We believe that the most accurate information is found directly in the scientific source. View abstract. Nausea 4. This may be a consequence of the expression of diverse cytokines that promote tumor growth (IFNy and IL-4 were decreased, while TGFβ1, IL-10, and IL-1b were increased) [60]. Uncontrolled Blood Sugar: How Dangerous Is It? Levels of alanine transaminase (ALT), a marker of liver inflammation, were significantly reduced in 85% of 18 hepatitis C patients treated with C. pyrenoidosa extract for 12 weeks [34]. View abstract. But in many cases, headache, joint pain, brain fog etc. A study performed in 125 patients with major depressive disorder showed improvement in depression and anxiety in patients who consumed C. vulgaris tablets in addition to their standard antidepressant medications for 6 weeks. It reduced cataract formation in diabetic rats by decreasing oxidative stress in the lens [19]. C. vulgaris reduced SOD levels in cells and thereby slowed cell aging [65]. View abstract. However, there are some potential side effects reported, as well. It protected mice from E. coli and Listeria monocytogenes infection in two animal trials [26, 27]. Chlorella is generally considered safe and well-tolerated. High levels of cholesterol or other fats (lipids) in the blood (, Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic. Be sure to have your blood checked regularly. Although superoxide dismutase (SOD) is an antioxidant enzyme, it produces hydrogen peroxide that has to be removed by GPx and catalase. In a placebo-controlled study performed in 10 female athletes, 5 weeks of Chlorella supplementation prevented the decrease in immune function (measured by salivary immunoglobulin A) during a training camp [23]. Detoxification. Contraindications / side effects to the use of Chlorella Chlorella for detoxification The liver as an organ of detoxification ... protect against the adverse effects of toxic minerals. Ng TP, Tan WC, Lee YK. More importantly, we have no strong evidence to show that it will do you any good. Chlorella is likely safe for a general population. is a clickable link to peer-reviewed scientific studies. Recently, a meta-analysis of 19 randomized control trials with 797 subjects revealed that Chlorella significantly decreases total and LDL cholesterol [13]. Lycopene extracted from Chlorella (C. marina) suppressed the growth and induced the cell death of human prostate cancer cells [59]. Some people who take sun chlorella may suffer from gastrointestinal problems including gas, abdominal pain, nausea, diarrhea and/or constipation. Salisbury, F. B. Joseph I. Gitelson and the Bios-3 project. In another animal trial, it decreased ulcer incidence in stressed rats [75]. CMAJ 2003;169:111-7.. View abstract. View abstract. Food Addit Contam 1988;5:103-9.. View abstract. View abstract. Align your health hacks with your genes for optimal health & cognitive function. The medicinal properties and nutritional value of Chlorella can help shield the heart, brain, liver, and more. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. View abstract. Additional side effects may include fatigue, irritability and increased sensitivity to sun exposure. Complement Ther Med 2015;23(4):598-602. Early research shows that taking chlorella tablets for 6 weeks might strengthen the. Nausea and vomiting 2. Chlorella will probably not hurt you (unless youre allergic to it), but we have no studies on the effects of long-term use. Tiredness in people treated with cancer drugs. All rights reserved. The same conce… He found a way to merge his two biggest passions—writing and health—and use them for noble purposes. Your email address will not be published. Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding. Detoxification of chlorella supplement on heterocyclic amines in Korean young adults. (2008) ^ a b Merchant RE, Carmack CA, Wise CM. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Krcmery V Jr. If you are worried about the side effects of doing a heavy metal detox using supplements such as cilantro and chlorella, you are not alone. A study performed in 80 individuals (with normal-high levels of blood pressure and borderline hypertension), showed that those who consumed GABA-rich Chlorella tablets for 12 weeks reduced their blood pressure significantly [21]. Another study of 70 fatty liver disease patients showed that Chlorella enhanced patients’ condition by reducing weight and blood glucose levels and decreasing inflammatory indicators (TNF-a and high-sensitivity C-reactive protein) [14]. In rats, Chlorella promoted dioxins excretion into feces by inhibiting the absorption of dioxins from the digestive tract [39, 40]. Below is a summary of up-to-date animal studies, cell-based research, or low-quality clinical trials which should spark further investigation. In stroke-prone rats with high blood pressure, Chlorella powder (C. regularis), containing carotenoids and arginine, improved blood vessel function, decreased the incidence of stroke, and increased lifespan [81]. Photo: How do you avoid Chlorella side effects..? View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . In a study of 70 pregnant women, Chlorella supplementation (6 g daily, from the 12th-18th week of pregnancy) reduced the risk of anemia by 48%, compared to control [47]. 1978;43(4):271-273. Another species of Chlorella (C. sorokiniana), killed human lung cancer cells and reduced tumor growth in mice (by decreasing cell-survival factors Bcl-2, survivin, and XIAP, and increasing cell death causing Bax) [56]. However, one person also experienced severe nausea and vomiting after a few weeks of Chlorella supplementation. This list does not cover all possible side effects. Turns out, chlorophyll is linked to natural cancer prevention, blocks carcinogenic effects within the body and protects DNA from damage caused by toxic molds like aflatoxin — very similar to way in which chlorophyll-rich chlorella has anticancer effects. Fatigue. With that said, chlorella can cause side effects, especially during the first few weeks of treatment. Chlorella ellipsoidea reduced the activation of nuclear factor kappa B (NFκB), thus lowering inflammation in a type of white blood cell (macrophage) of mice fed with a high-fat and high-cholesterol diet [11]. In a placebo-controlled study with 57 borderline diabetic patients, Chlorella tablets for 12 weeks alleviated some features of type 2 diabetes by decreasing resistin production and increasing adiponectin receptor (ADIPOR1) [15]. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Minor side effects are relatively common and may occur in as many as 18% of consumers. Int.Immunopharmacol. Chlorella minutissima extract increased antioxidant enzymes (GST) while it decreased the activity of enzymes involved in skin disorders (tyrosinase and elastase). A Chlorella component (Chlorella 11-peptide) suppressed the inflammatory cytokine TNF-alpha and an inflammatory mediator (nitric oxide) in both injured rats and white blood cell cultures (macrophages) [12]. People allergic to moldmay also be allergic to chlorella. Low levels of iron in women who are pregnant. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Anti-tumor-promoting glyceroglycolipids from the green alga, Chlorella vulgaris. Depression. View abstract. View abstract. Required fields are marked *. Dioxins are highly toxic, cancer-causing chemicals. Today, Chlorella is being used in Japan, the USA, Europe, and other countries. The bone marrow suppression may result in death. Another study suggested that some Chlorella extracts have an inhibitory effect on Propionibacterium acnes, a bacterium that has been described as one of the major causes of acne [77]. In this article, we are going to discuss the health benefits of chlorella for liver detoxification. On the other hand, spirulina improves hemoglobin, protein, and vitamin levels in malnourished children, increases immune function, has a great antioxidant capacity, and is a good source of beta-carotene [87]. Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome. Contact your doctor or pharmacist if you notice any other side effects. Neurosci Lett. Chlorella is POSSIBLY SAFE when taken by mouth, short-term (up to 2 months).The most common side effects include diarrhea, nausea, gas (), green discoloration of the stools, and stomach cramping, especially in the first week of use.. Chlorella has caused serious allergic reactions, including asthma and other dangerous breathing problems.. Chlorella can cause skin to become extra sensitive … Tiberg, E., Rolfsen, W., Einarsson, R., and Dreborg, S. Detection of Chlorella-specific IgE in mould-sensitized children. Learn how your comment data is processed. J Med Food. Peirce A. Chlorella (Parachlorella beijerinckii) prevented cognitive decline in mouse models of dementia by reducing oxidative stress and inflammation [66]. Chlorella is possibly safe during pregnancy, but pregnant women should use it only if prescribed by their doctor [47]. Supplement-drug interactions can be dangerous and, in rare cases, even life-threatening. WebMD does not provide medical advice, diagnosis or treatment. Chlorella and spirulina are safe to be taken as whole food supplements, but some consumers have reported mild reactions. The same person previously practiced long-term spirulina supplementation with no side effects. Never delay or disregard seeking professional medical advice because of something you have read on SelfDecode. The dose of your warfarin (Coumadin) might need to be changed. Chlorella is POSSIBLY SAFE when taken by mouth, short-term (up to 2 months). Early research shows that taking chlorella during pregnancy does not reduce the risk of high blood pressure. Chlorella and spirulina are types of blue-green algae often consumed in supplement form. SelfDecode provides recommendations that are. CONDITIONS OF USE AND IMPORTANT INFORMATION: This extract could be potentially used in cosmetic products for irritated, reactive, and aging skin [76]. There are no major (life-threatening) side effects associated with chlorella. Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Hasegawa, T., Matsuguchi, T., Noda, K., Tanaka, K., Kumamoto, S., Shoyama, Y., and Yoshikai, Y. Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris. These types of reactions are called Herxheimer reactions. Furthermore, Chlorella is sold extensively as a supplement or nutraceutical product [4, 5]. Early research shows that taking chlorella tablets plus chlorella liquid extract might help people with a type of brain tumor called glioma better tolerate chemotherapy and radiation treatments. Haidari F, Homayouni F, Helli B, Haghighizadeh MH, Farahmandpour F. Effect of chlorella supplementation on systematic symptoms and serum levels of prostaglandins, inflammatory and oxidative markers in women with primary dysmenorrhea. Also in mice, C. vulgaris prevented the immunosuppressive effects caused by stress [29]. So you read the title and see the words “side effects” and I bet you are thinking that this is going to be about how spirulina is bad for your liver. One user experienced severe digestive discomfort which they think was caused by too strong detox process. Phytochemistry 1995;40:1433-7. J.Med.Food 2002;5(3):141-152. Welcome to the final article of our Liver Detox 101 series! The adverse effects disappeared upon the supplement cessation. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Ryu NH, Lim Y, Park JE, et al. Vision problems 11. View abstract. Phytother Res 2000;14:167-73. Chlorella improved the condition of mice with muscle atrophy by reducing oxidative stress and decreasing creatine phosphatase levels (a muscle impairment marker); it also helped to maintain the activity of the mitochondrial cytochrome c oxidase [71]. Information from this source is evidence-based and objective, and without commercial influence. View abstract. Rinsho Shinkeigaku 1995;35(7):806-807. ♦ It can increase the level of uric acid in the body, raising the risk of heart disease. But chlorella does not seem to slow the progression of the cancer or improve survival. Chidley C, Davison G. The effect of Chlorella pyrenoidosa supplementation on immune responses to 2 days of intensified training. Chlorella is a type of single-celled green alga (microalga) that is usually found in freshwater environments. According to preliminary research, Chlorella increases insulin sensitivity, enhances immune system function, counteracts the effects of free radicals, and decreases blood pressure [5]. Since chlorella also contains iodine, it can cause reactions in people with iodine sensitivity. Panahi Y, Badeli R, Karami GR, Badeli Z, Sahebkar A. People with liver or kidney problems may need lower doses. A study of 35 pregnant women showed increased IgA levels in the breast milk of women that consumed Chlorella for 6 months before giving birth. C. vulgaris may have an anti-aging effect because it [61]: Cells age when the telomeres (ends of chromosomes) are shortened. Flatulence 2. The Sun Chlorella powder-supplement is said to have many health benefits. Chlorella: Opinions of … In a mouse model of Parkinson’s, polysaccharides from C. pyrenoidosa prevented the loss of dopamine and neuron death, inhibited inflammation, improved symptoms, and delayed disease progression [80]. View abstract. Resp Med 1994;88:555-7. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. View abstract. Although the most frequently studied types of Chlorella are quite similar (Chlorella vulgaris and Chlorella pyrenoidosa), the composition may vary among different species [7, 6]. View abstract. Merchant RE, Carmack CA, Wise CM. Jonathan Ritter, PharmD, PhD (Pharmacology), Eleuthero (Siberian Ginseng) Root Dosage & Side Effects, The Renal Diet: Foods to Eat & Avoid in Kidney Disease, Top 17 Negative Health Effects of Environmental Pollution, removes free radicals (due to its high levels of antioxidants), Reducing white blood cells infiltration into the skin (eosinophils and mast cells), Decreasing pro-inflammatory mediators (thymus- and activation-regulated chemokine and macrophage derived-chemokine). New phytophotodermatosis. … (check all that apply). They include [82, 5]: Pre-existing medical conditions, such as renal failure and hypothyroidism, but not Hashimoto’s thyroiditis, increase the risk of side effects [82]. This result could be explained by the neuroprotective components contained in C. vulgaris (linoleic acid and vitamin B12/methylcobalamin), which have been reported to improve depressive symptoms [51]. Spirulina and chlorella are naturally occurring whole foods and, generally speaking, do not cause any significant side effects. On the other hand, a study revealed how C. vulgaris promoted breast cancer growth in mice when given in high doses (200 mg/kg). Further research is needed to investigate the potential antidepressant effects of Chlorella. It also helps to reduce the amount of certain harmful chemicals found in food. Some suggest that Chlorella may interfere with immunosuppressive drugs. The following side-effects have been reported from taking chlorella:16 1. nausea 2. stomach discomfort Shop Superfood Supplements Advice is for information only and should not replace medical care. Early research shows that taking chlorella might reduce the risk of. Due to its high concentration of protein (50%), Chlorella is a good source of the essential amino acids required for our nutrition [6]. By increasing the immune system, chlorella might decrease the effectiveness of medications that are used to decrease the immune system. Phytother Res 1990;4:220-31. Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial. View abstract. In mice, C. vulgaris prevented psychological stress by suppressing the increase in serum corticosterone levels (a mouse analog of cortisol) [73]. Join SelfHacked today and start the journey of improving your life, Get the Regimen of A Top Biohacker Preparing His Body to Fight Coronavirus, Avoid Illness By Using the Best Supplements For Your Body. 2012;32(2):85-92. Common side effects include bone marrow suppression, nausea, and diarrhea. Taking chlorella supplements can also lead to sun sensitivity. Planta Med. Constipation 4. The opinions expressed in this section are solely from the users who may or may not have a medical background.

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